TABLE 5.
MIC values for S. aureus (ATCC 29213) grown in MHB or MHB with 50% human seruma
| Compound | Median MIC (μg/ml) with: |
Fold change of MIC | % binding to: |
||
|---|---|---|---|---|---|
| No serum | 50% serum | Mouse plasma | Human plasma | ||
| VAN | 1 | 2 | 2 | 25b | 55c |
| NOV | 0.13 | 16 | 128 | ND | 95c |
| LNZ | 2 | 2 | 1 | 39.5 | 31c |
| CIP | 0.13 | 0.25 | 2 | ND | 20–40c |
| 1614 | 2 | 32 | 16 | 96.5 | ND |
| 1717 | 0.06 | 1 | 16 | 97.6 | 95.4 |
| 2069 | 0.25 | 16 | 64 | 99.6 | ND |
| 2093 | 0.06 | 8 | 128 | 99.9 | ND |
| 2144 | 0.06 | 4 | 64 | 98.4 | ND |
a
Data are from three experiments. Experimental or published values for plasma protein binding are also shown. Abbreviations: CIP, ciprofloxacin; LNZ, linezolid; ND, not done; NOV, novobiocin; VAN, vancomycin.
b
Data are from reference 48.
c
Data are from the DrugBank database (www.drugbank.ca).