TABLE 6.
Analysis of time to culture conversion by actual dose of rifampin received and by exposure to rifampina
| Parameter | MGIT |
LJ |
||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Actual wt-adjusted dose of rifampin received (≥16 mg/kg vs <16 mg/kg) | 1.20 (0.80, 1.82) | 0.376 | 1.22 (0.85, 1.75) | 0.271 |
| AUC0–24 of rifampin (≥48 mg · h/liter vs <48 mg · h/liter) | 0.50 (0.22, 1.13) | 0.096 | 1.39 (0.77, 2.51) | 0.276 |
| Cmax of rifampin (≥9.12 mg/liter vs <9.12 mg/liter) | 0.73 (0.34, 1.60) | 0.436 | 1.42 (0.79, 2.56) | 0.240 |
| AUC0–24 of rifampin (per 1 unit) | 0.99 (0.98–1.01) | 0.432 | 1.01 (1.00–1.02) | 0.140 |
| Cmax of rifampin (per 1 unit) | 0.99 (0.91–1.07) | 0.703 | 1.03 (0.98–1.09) | 0.211 |
a
AUC0–24, area under the concentration-versus-time curve up to 24 h after the dose; Cmax, maximum plasma concentration; LJ, Lowenstein-Jensen medium; MGIT, mycobacterial growth indicator tube; CI, confidence interval.