TABLE 1.
Type of mutations found in WNV populations untreated or treated with 1 mM favipiravira
| WNV population | No. of mutated clones/total | No. of deletions | No. of mutationsb |
Total nucleotides sequenced | |||
|---|---|---|---|---|---|---|---|
| A→G | U→C | G→A | C→U | ||||
| Untreated | 10/48 | 0 | 4 (0.01) | 2 (0.01) | 0 (0.00) | 8 (0.04) | 43,632 |
| Treated | 32/43** | 1 | 26** (0.1)* | 9* (0.05) | 21** (0.08)* | 13 (0.06) | 39,087 |
a
Shown are the number of mutated clones and type of mutated nucleotides observed in the untreated or favipiravir-treated WNV population relative to the consensus sequence. The proportion of each type of mutation normalized to the number of each nucleotide type in the 909-base fragment sequenced is given in parentheses.
b
Statistically significant differences compared to untreated samples are indicated: *, P = 0.05, and **, P < 0.0001, by Fisher's exact test and χ2 test with Yates' correction, respectively.