TABLE 5.
Impact of antibiotic resistance on the eradication rate
| Resistance | Eradication rate |
|||
|---|---|---|---|---|
| ITT analysis |
PP analysis |
|||
| No./total (%) | P value | No./total (%) | P value | |
| Bismuth quadruple therapy (n = 38) | ||||
| Clarithromycin-resistant | 1.00 | 1.00 | ||
| − | 28/32 (87.5) | 27/31 (87.1) | ||
| + | 6/6 (100) | 6/6 (100) | ||
| Amoxicillin-resistant | 1.00 | 1.00 | ||
| − | 33/37 (89.2) | 32/36 (88.9) | ||
| + | 1/1 (100) | 1/1 (100) | ||
| Metronidazole-resistant | 0.04b | 0.05 | ||
| − | 27/28 (96.4) | 26/27 (96.3) | ||
| + | 7/10 (70) | 7/10 (70) | ||
| Tetracycline | —c | — | ||
| − | 34/38 (89.5) | 33/37 (89.2) | ||
| + | — | — | ||
| Dual-resistanta | 1.00 | 1.00 | ||
| − | 32/36 (88.9) | 31/35 (88.6) | ||
| + | 2/2 (100) | 2/2 (100) | ||
| Hybrid therapy (n = 34) | ||||
| Clarithromycin-resistant | 0.17 | 0.17 | ||
| − | 28/28 (100) | 28/28 (100) | ||
| + | 5/6 (83.3) | 5/6 (83.3) | ||
| Amoxicillin-resistant | — | — | ||
| − | 33/34 (97.1) | 33/34 (97.1) | ||
| + | — | — | ||
| Metronidazole-resistant | 1.00 | 1.00 | ||
| − | 25/26 (96.2) | 25/26 (96.2) | ||
| + | 8/8 (100) | 8/8 (100) | ||
| Tetracycline | — | — | ||
| − | 33/34 (97.1) | 33/34 (97.1) | ||
| + | — | — | ||
| Dual-resistanta | 1.00 | 1.00 | ||
| − | 30/31 (96.8) | 30/31 (96.8) | ||
| + | 3/3 (100) | 3/3 (100) | ||
a
Dual-resistant (resistances to both clarithromycin and metronidazole).
b
P < 0.05.
c
—, not applicable.