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Visual predictive checks for colistin in plasma following DPI of 0.66 mg base/kg (A) and 1.32 mg base/kg (B) and i.v. administration of 0.66 mg base/kg (C). Solid line, the median model-predicted concentrations (P50); broken lines, model-predicted 10th percentile (P10) and 90th percentile (P90) concentrations; solid dots, observed concentrations. After 4 h, the 10th percentile concentration approaches zero. *, the concentration is below the LOQ (0.10 mg/liter).
