TABLE 2.

Estimated values of population PK parameters for colistin in healthy rats following DPI or i.v. administration

Parameter	Description	Unit	Estimated value	SE (%)
VE1	Vol of distribution in ELF1 (ELF compartment)	liter/kg	2.90 × 10−5	35.7
VE2	Vol of distribution in ELF2 (peripheral lung compartment)	liter/kg	9.67 × 10−4	18.8
Vc	Volume of distribution in central plasma compartment	liter/kg	0.572	17.9
Vp	Volume of distribution in peripheral plasma compartment	liter/kg	1.47	35.3
CLD, ELF	ELF intercompartmental clearance	liter/h/kg	4.26 × 10−4	37.8
CLD, plasma	Plasma intercompartmental clearance	liter/h/kg	0.172	24.3
CLtotal	Total systemic body clearance	liter/h/kg	0.271	2.51
CLELF, plasma	Intercompartmental clearance from ELF to plasma	liter/h/kg	4.03 × 10−4	15.0
CLplasma, ELF	Intercompartmental clearance from plasma to ELF	liter/h/kg	9.93 × 10−7	46.0
fu	Unbound fraction		0.44 (fixed)	NAa
FDPI	Bioavailability	%	46.5	8.43

^aNA, not applicable.