TABLE 1.
Antimicrobial activity of ceftazidime-avibactam tested against antimicrobial resistant Enterobacteriaceae and P. aeruginosa from U.S. hospitals (2013 to 2016)a
| Organism (no. of isolates) | No. of isolates and cumulative % at various MICs (μg/ml)b |
MIC (μg/ml) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | MIC50 | MIC90 | |
| Enterobacteriaceae (36,380) | 1,334 | 4,428 | 11,139 | 12,342 | 4,815 | 1,631 | 448 | 142 | 63 | 15 | 13 | 1 | 9 | 0.12 | 0.25 |
| 3.7 | 15.8 | 46.5 | 80.4 | 93.6 | 98.1 | 99.3 | 99.7 | 99.9 | 99.9 | >99.9 | >99.9 | 100.0 | |||
| CRE (513) | 16 | 5 | 13 | 35 | 76 | 137 | 138 | 59 | 20 | 1 | 4 | 0 | 9 | 0.5 | 2 |
| 3.1 | 4.1 | 6.6 | 13.5 | 28.3 | 55.0 | 81.9 | 93.4 | 97.3 | 97.5 | 98.2 | 98.2 | 100.0 | |||
| MDR (2,953) | 98 | 217 | 428 | 597 | 587 | 525 | 296 | 116 | 53 | 13 | 13 | 1 | 9 | 0.25 | 1 |
| 3.3 | 10.7 | 25.2 | 45.4 | 65.3 | 83.0 | 93.1 | 97.0 | 98.8 | 99.2 | 99.7 | 99.7 | 100.0 | |||
| XDR (448) | 16 | 9 | 20 | 25 | 53 | 126 | 117 | 44 | 23 | 5 | 4 | 0 | 6 | 0.5 | 2 |
| 3.6 | 5.6 | 10.0 | 15.6 | 27.5 | 55.6 | 81.7 | 91.5 | 96.7 | 97.8 | 98.7 | 98.7 | 100.0 | |||
| E. coli (12,942) | 1,024 | 1,463 | 4,597 | 4,550 | 1,066 | 186 | 36 | 13 | 3 | 1 | 0 | 0 | 3 | 0.06 | 0.25 |
| 7.9 | 19.2 | 54.7 | 89.9 | 98.1 | 99.6 | 99.8 | 99.9 | >99.9 | >99.9 | >99.9 | >99.9 | 100.0 | |||
| Ceftriaxone-NS (1,750) | 100 | 63 | 247 | 736 | 444 | 108 | 33 | 12 | 3 | 1 | 0 | 0 | 3 | 0.12 | 0.25 |
| 5.7 | 9.3 | 23.4 | 65.5 | 90.9 | 97.0 | 98.9 | 99.6 | 99.8 | 99.8 | 99.8 | 99.8 | 100.0 | |||
| MEM-NS (27) | 1 | 1 | 3 | 5 | 8 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 0.25 | >32 |
| 3.7 | 7.4 | 18.5 | 37.0 | 66.7 | 81.5 | 85.2 | 88.9 | 88.9 | 88.9 | 88.9 | 88.9 | 100.0 | |||
| K. pneumoniae (7,511) | 137 | 364 | 2,523 | 2,950 | 957 | 364 | 137 | 58 | 17 | 0 | 1 | 0 | 3 | 0.12 | 0.25 |
| 1.8 | 6.7 | 40.3 | 79.5 | 92.3 | 97.1 | 98.9 | 99.7 | 99.9 | 99.9 | >99.9 | >99.9 | 100.0 | |||
| MEM-NS (382) | 15 | 5 | 7 | 21 | 56 | 111 | 99 | 48 | 16 | 0 | 1 | 0 | 3 | 0.5 | 2 |
| 3.9 | 5.2 | 7.1 | 12.6 | 27.2 | 56.3 | 82.2 | 94.8 | 99.0 | 99.0 | 99.2 | 99.2 | 100.0 | |||
| Ceftriaxone-NS (1,063) | 39 | 23 | 67 | 259 | 242 | 229 | 127 | 56 | 17 | 0 | 1 | 0 | 3 | 0.25 | 1 |
| 3.7 | 5.8 | 12.1 | 36.5 | 59.3 | 80.8 | 92.8 | 98.0 | 99.6 | 99.6 | 99.7 | 99.7 | 100.0 | |||
| Colistin-NS (205) | 9 | 4 | 22 | 49 | 30 | 36 | 32 | 13 | 9 | 0 | 0 | 0 | 1 | 0.25 | 2 |
| 4.4 | 6.3 | 17.1 | 41.0 | 55.6 | 73.2 | 88.8 | 95.1 | 99.5 | 99.5 | 99.5 | 99.5 | 100.0 | |||
| K. oxytoca (1,902) | 8 | 93 | 823 | 709 | 174 | 74 | 14 | 5 | 1 | 1 | 0.12 | 0.25 | |||
| 0.4 | 5.3 | 48.6 | 85.9 | 95.0 | 98.9 | 99.6 | 99.9 | 99.9 | 100.0 | ||||||
| Proteus mirabilis (2,818) | 42 | 1,568 | 1,102 | 83 | 14 | 3 | 3 | 0 | 1 | 1 | 0 | 0 | 1 | 0.03 | 0.06 |
| 1.5 | 57.1 | 96.2 | 99.2 | 99.7 | 99.8 | 99.9 | 99.9 | 99.9 | >99.9 | >99.9 | >99.9 | 100.0 | |||
| E. cloacae (3,740) | 33 | 26 | 215 | 1,594 | 1,184 | 477 | 164 | 33 | 8 | 0 | 3 | 1 | 2 | 0.25 | 0.5 |
| 0.9 | 1.6 | 7.3 | 49.9 | 81.6 | 94.4 | 98.7 | 99.6 | 99.8 | 99.8 | 99.9 | 99.9 | 100.0 | |||
| CAZ-NS (831) | 13 | 3 | 7 | 44 | 229 | 345 | 146 | 30 | 8 | 0 | 3 | 1 | 2 | 0.5 | 1 |
| 1.6 | 1.9 | 2.8 | 8.1 | 35.6 | 77.1 | 94.7 | 98.3 | 99.3 | 99.3 | 99.6 | 99.8 | 100.0 | |||
| E. aerogenes (1,384) | 29 | 47 | 352 | 605 | 256 | 75 | 10 | 4 | 5 | 0 | 1 | 0.12 | 0.25 | ||
| 2.1 | 5.5 | 30.9 | 74.6 | 93.1 | 98.6 | 99.3 | 99.6 | 99.9 | 99.9 | 100.0 | |||||
| CAZ-NS (279) | 10 | 7 | 17 | 64 | 113 | 49 | 9 | 4 | 5 | 0 | 1 | 0.25 | 0.5 | ||
| 3.6 | 6.1 | 12.2 | 35.1 | 75.6 | 93.2 | 96.4 | 97.8 | 99.6 | 99.6 | 100.0 | |||||
| Morganella morganii (1,059) | 2 | 370 | 489 | 120 | 40 | 25 | 9 | 2 | 1 | 0 | 1 | 0.06 | 0.12 | ||
| 0.2 | 35.1 | 81.3 | 92.6 | 96.4 | 98.8 | 99.6 | 99.8 | 99.9 | 99.9 | 100.0 | |||||
| Citrobacter koseri (777) | 34 | 94 | 373 | 205 | 60 | 10 | 0 | 1 | 0.06 | 0.12 | |||||
| 4.4 | 16.5 | 64.5 | 90.9 | 98.6 | 99.9 | 99.9 | 100.0 | ||||||||
| Citrobacter freundii (1,026) | 12 | 15 | 171 | 473 | 225 | 98 | 23 | 2 | 6 | 1 | 0.12 | 0.5 | |||
| 1.2 | 2.6 | 19.3 | 65.4 | 87.3 | 96.9 | 99.1 | 99.3 | 99.9 | 100.0 | ||||||
| Serratia marcescens (1,715) | 4 | 49 | 720 | 668 | 233 | 31 | 5 | 1 | 2 | 2 | 0.25 | 0.5 | |||
| 0.2 | 3.1 | 45.1 | 84.0 | 97.6 | 99.4 | 99.7 | 99.8 | 99.9 | 100.0 | ||||||
| Proteus vulgaris (418) | 3 | 186 | 185 | 38 | 2 | 4 | 0.06 | 0.12 | |||||||
| 0.7 | 45.2 | 89.5 | 98.6 | 99.0 | 100.0 | ||||||||||
| Providencia spp. (872) | 5 | 164 | 184 | 231 | 149 | 74 | 14 | 19 | 18 | 9 | 5 | 0.12 | 0.5 | ||
| 0.6 | 19.4 | 40.5 | 67.0 | 84.1 | 92.5 | 94.2 | 96.3 | 98.4 | 99.4 | 100.0 | |||||
| P. aeruginosa (7,868) | 141 | 388 | 2,771 | 2,779 | 1,137 | 426 | 134 | 43 | 49 | 2 | 4 | ||||
| 1.8 | 6.7 | 41.9 | 77.3 | 91.7 | 97.1 | 98.8 | 99.4 | 100.0 | |||||||
| CAZ-NS (1,204) | 1 | 1 | 7 | 93 | 317 | 344 | 216 | 133 | 43 | 49 | 4 | 16 | |||
| 0.1 | 0.2 | 0.7 | 8.5 | 34.8 | 63.4 | 81.3 | 92.4 | 95.9 | 100.0 | ||||||
| MEM-NS (1,471) | 4 | 8 | 121 | 382 | 485 | 282 | 107 | 37 | 45 | 4 | 16 | ||||
| 0.3 | 0.8 | 9.0 | 35.0 | 68.0 | 87.2 | 94.4 | 96.9 | 100.0 | |||||||
| P-T-NS (1,497) | 2 | 1 | 15 | 108 | 360 | 467 | 336 | 125 | 39 | 44 | 4 | 16 | |||
| 0.1 | 0.2 | 1.2 | 8.4 | 32.5 | 63.7 | 86.1 | 94.5 | 97.1 | 100.0 | ||||||
| CAZ, MEM, and P-T-NS (628) | 22 | 106 | 174 | 149 | 101 | 35 | 41 | 8 | 32 | ||||||
| 3.5 | 20.4 | 48.1 | 71.8 | 87.9 | 93.5 | 100.0 | |||||||||
| MDR (1,562) | 8 | 18 | 129 | 384 | 498 | 314 | 122 | 42 | 47 | 4 | 16 | ||||
| 0.5 | 1.7 | 9.9 | 34.5 | 66.4 | 86.5 | 94.3 | 97.0 | 100.0 | |||||||
| XDR (717) | 1 | 0 | 1 | 32 | 126 | 190 | 194 | 93 | 36 | 44 | 8 | 32 | |||
| 0.1 | 0.1 | 0.3 | 4.7 | 22.3 | 48.8 | 75.9 | 88.8 | 93.9 | 100.0 | ||||||
a
Abbreviations: CRE, carbapenem-resistant Enterobacteriaceae; MDR, multidrug resistant; XDR, extensively drug resistant; NS, nonsusceptible; MEM, meropenem; CAZ, ceftazidime; P-T, piperacillin-tazobactam.
b
For each entry in column 1, there are two rows of data. The first row indicates the number of strains, and the second row indicates the cumulative percentage. Column subheadings specify the various MICs in μg/ml.