TABLE 2.
MICs of BDQ against M. abscessus S strains carrying single point mutations in atpE either on a pMV261-derived multicopy plasmid or in the chromosome
| Strain, plasmid, or mutation | MIC (μg/ml)a |
||
|---|---|---|---|
| BDQ | CFZ | IMP | |
| CIP104536T (S) | 0.06 | 0.5 | 8 |
| Multicopy plasmid | |||
| pMV261 | 0.125 | 0.5 | 8 |
| pAtpE | 0.125 | 0.5 | 8 |
| pAtpED29V | 0.125 | 1 | 8 |
| pAtpEA64P | 0.125 | 1 | 8 |
| Chromosomal mutation | |||
| atpE_D29V | 16 | 0.5 | 8 |
| atpE_A64P | 16 | 0.5 | 8 |
a
The MIC was determined in cation-adjusted Mueller-Hinton broth. Data are representative of two independent experiments. BDQ, bedaquiline; CFZ, clofazimine; IMP, imipenem.