FIG 3.

Dissection of phagocyte-dependent and -independent bactericidal activities of A1124 in human blood. Bacteria were added to heparinized blood pretreated with either cytochalasin D (CytD+) or its buffer as control (CytD-) and test antibodies and incubated for 3 h. Surviving bacterial count was correlated with the input number of bacteria. Data from 9 independent experiments using blood samples of 5 different donors are shown. Statistical analysis was performed using the Wilcoxon matched-pair signed-rank test, and P values are indicated on the graph.