FIG 6.

Protective efficacy of A1124 in a murine model of endotoxemia. Groups of 5 BALB/cJRj mice were passively immunized with various concentrations of A1124 IgG (A) or equimolar amounts of IgG and its fragments with respect to antigen-binding sites (B). Challenge with a lethal dose (2 ng) of purified ST131 LPS was performed in GalN-sensitized mice 24 h (A) or 2 h (B) postimmunization. Lethality was monitored daily for up to 10 days postchallenge. Kaplan-Meier plots show combined results of two independent experiments with a total of 10 mice/group and P values calculated by means of the log rank (Mantel-Cox) test.