FIG 7.

Protective efficacy of A1124 in rodent models of bacteremia. Animals were immunized with the indicated doses of MAbs and subsequently challenged intravenously with a lethal dose of E. coli ST131. (A) Murine model with a total of 10 mice per group (two identical experiments with 5 mice each) challenged with strain 81009. (B) Rat model with 5 animals per group challenged with strain 3O. In both models, animals were observed daily for 10 days postinfection. Differences in survival between the A1124- and the control MAb-treated groups were statistically compared by means of the log rank (Mantel-Cox) test with P values indicated.