FIG 8.

The role of the complement system in antibody-mediated protection in the murine model of bacteremia. Groups of 5 mice were dosed with the indicated amounts of cobra venom factor (CVF) or its buffer (control group) and subsequently passively immunized with 10 μg of A1124 or an irrelevant control MAb (control group). The next day, the animals were challenged intravenously with a lethal dose of E. coli ST131 strain 81009. Survival was monitored for up to 10 days postchallenge. Kaplan-Meier curves obtained from two independent experiments (with a total of 10 mice per group) are shown, except for the group marked with # (one experiment with n = 5 mice), and P values were calculated by means of the log rank (Mantel-Cox) test.