TABLE 3.

Results of model selection^a

Parameter	Model	OFV	ΔOFV	Reference model	P valueb (LRT)
Structural model
Base model (no IOV), one compartment	1	281.6
One-compartment model with IOV on CL	2	195.43	86.17	1	<0.0001
Covariate model
BMI on CL	4	195.79	0.36	2	0.55
Sex on V	5	190.22	5.21	2	0.022
Disease on CL	7	191.59	3.84	2	0.050
Baseline ALT concn on CL	8	190.23	5.20	2	0.023
Baseline AST concn on CL	9	195.5	0.07	2	0.79
Baseline total bilirubin concn on CL	10	195.01	0.42	2	0.52
Baseline conjugated bilirubin concn on CL	11	194.00	1.43	2	0.23
Baseline ALK concn on CL	12	195.82	0.39	2	0.53
Baseline GGT concn on CL	13	196.16	0.73	2	0.39
Longitudinal ALT concn on CL	14	193.19	2.24	2	0.13
Longitudinal AST concn on CL	15	195.24	0.19	2	0.66
Longitudinal total bilirubin concn on CL	16	195.37	0.06	2	0.81
Longitudinal conjugated bilirubin concn on CL	17	195.26	0.17	2	0.68
Longitudinal ALK concn on CL	18	191.82	3.61	2	0.057
Longitudinal GGT concn on CL	19	193.92	1.51	2	0.22

^aOFV, objective function value; ΔOFV, difference in OFV; LRT, likelihood ratio test; IOV, interoccasion variability; longitudinal, the use of dynamic values changing within the same period of observation.

^bP values in bold indicate statistically significant differences.