TABLE 4.

Results of Monte Carlo simulations

Regimen and time of concn determination	% of patients achieving the following concn:
	<0.5 μg/ml	≥0.7 μg/ml	≥1.0 μg/ml	≥1.5 μg/ml	≥2.0 μg/ml
Standard regimen (300 mg BID and then 300 mg QD)
48 h	1.0	95.6	72.6	16.0	2.6
Day 10	2.6	93.0	76.8	49.2	24.6
Lowered-dose regimen of 300 mg BID, 300 mg on day 2, and then 200 mg QD
48 h	1.0	95.6	72.6	16.0	2.6
Day 10	9.2	74.4	50.8	18.4	5.2
Lowered-dose regimen of 200 mg BID and then 200 mg QD
48 h	6.2	66.8	16.0	0.6	0.0
Day 10	9.4	74.4	49.2	15.4	4.4
Lowered-dose regimen of 300 mg BID, 300 mg on day 2, and then 100 mg QD
48 h	1.0	95.6	72.6	16.0	2.6
Day 10	44.4	29.0	11.0	1.0	0.2