FIG 1.

Effects of subinhibitory dalbavancin concentrations on S. aureus extracellular toxin production. S. aureus strains were cultured in the presence of 1/16, 1/8, or 1/4 the MIC of dalbavancin, and results were compared to those seen with a no-treatment (NT) control. Levels of PVL and TSST-1 (in nanograms per milliliter) were determined by ELISA (top panel). Alpha-hemolysin (AH) was quantitated by rabbit erythrocyte lysis assay (in hemolytic units [HU] per ml) (bottom panel). Error bars represent the standard errors of results between biological replicates (n = 3). A hash mark (#) indicates that no toxin was detected, and an asterisk (*) indicates that data are significantly different from those determined with the NT control (P ≤ 0.05) at each corresponding time point based on an ANOVA with false-discovery-rate adjustments.