TABLE 5.
Effects of 24-h daptomycin exposure on isolate susceptibility
| Drug tested | Incubation with daptomycin | MIC50/MIC90 (μg/ml)a |
No. susceptible/total no. (%)b | No. nonsusceptible/total no. (%)b | |||
|---|---|---|---|---|---|---|---|
| MIC50 at 24 h | MIC90 at 24 h | MIC50 at 48 h | MIC90 at 48 h | ||||
| Daptomycin | Preincubation | 0.094 | 0.125 | NP | NP | 48/50 (96) | 2/50 (4) |
| Postincubation | >256 | >256 | NP | NP | 0/50 (0) | 50/50 (100) | |
| Vancomycin | Preincubation | 0.25 | 0.38 | 0.38 | 0.50 | 50/50 (100) | 0/50 (0) |
| Postincubation | 0.38 | 0.50 | 0.50 | 0.75 | 50/50 (100) | 0/50 (0) | |
| Telavancin | Preincubation | 0.012 | 0.016 | 0.016 | 0.023 | NA | NA |
| Postincubation | 0.012 | 0.016 | 0.012 | 0.016 | NA | NA | |
NP, not performed.
Based on CLSI M45, 3rd edition (26). NA, no interpretative data available.