TABLE 2.
Estimates of piperacillin pharmacokinetic parameters for the final covariate model
| Parametera | Mean (SD) | %CVb |
|---|---|---|
| CL (liters/h) | 18.02 (4.80) | 26.63 |
| V (h) | 14.30 (7.31) | 51.09 |
| Kcp (h−1) | 1.40 (1.35) | 96.28 |
| Kpc (h−1) | 4.99 (7.81) | 156.49 |
a
CL, clearance; V, volume of distribution of central compartment; Kcp, rate constant for piperacillin distribution from central to peripheral compartment; Kpc, rate constant for piperacillin distribution from peripheral to central compartment.
b
CV, coefficient of variation.