TABLE 7.
Comparison of model-predicted steady-state concentrations for low and high creatinine clearance
| CLCR (ml/min/1.73 m2) and simulated dosing regimen | Model-predicted Cssa |
||
|---|---|---|---|
| Median (mg/liters) | IQR (mg/liters) | Maximum Css/trough (mg/liters) | |
| 40 | |||
| 4.0 g q8h | 14.2 | 6.1–22.8 | 68.9 |
| 4.0 g q6h | 28 | 16.5–42.7 | 87.2 |
| 4.0 g q8h, 4-h EI | 25.8 | 5.0–39.8 | 74.8 |
| 4.0 g q6h, 3-h EI | 43.1 | 13.1–62.3 | 107.5 |
| 4.0-g LD + 8.0-g CI | 56.3 | 34.1–56.3 | 88.2 |
| 4.0-g LD + 12.0-g CI | 67.8 | 51.2–84.3 | 132.0 |
| 4.0-g LD + 16.0-g CI | 88.3 | 67.7–112.1 | 172.2 |
| 140 | |||
| 4.0 g q8h | 0.1 | BLOQ of −0.4 | 10.6 |
| 4.0 g q6h | 0.4 | 0.1–1 | 15.8 |
| 4.0 g q8h, 4-h EI | 0.591556 | 0.2–1.3 | 11.3 |
| 4.0 g q6h, 3-h EI | 1.803293 | 0.7–3.3 | 16.9 |
| 4.0-g LD + 8.0-g CI | 12.91229 | 10.8–16.1 | 25.6 |
| 4.0-g LD + 12.0-g CI | 19.36153 | 16.1–24.2 | 38.1 |
| 4.0-g LD + 16.0-g CI | 25.25549 | 21.3–32.0 | 49.5 |
a
Data for continuous infusion regimens are for steady-state concentration (Css) between 48 and 72 h and trough concentrations at 72 h for intermittent and extended infusion regimens. BLOQ, below the limit of quantification of the assay method for the model data (<0.1 mg/liter).