TABLE 1.
MIC results for paired Candida glabrata isolates
| Isolate type and antifungal drug | MIC (μg/ml)a |
|||||
|---|---|---|---|---|---|---|
| Range | Geometric mean | Median | Mode | MIC50 | MIC90 | |
| Resistant C. glabrata isolates (n = 34)b | ||||||
| SCY-078 | 0.25–4 | 0.72 | 0.5 | 0.5 | 0.5 | 4 |
| FLC | 1–128 | 12 | 16 | 4 | 16 | 128 |
| ANF | ≤0.015 to 4 | 0.29 | 0.37 | 0.03 | 0.25 | 2 |
| MCF | ≤0.015 to 4 | 0.16 | 0.18 | ≤0.015 | 0.12 | 2 |
| CAS | ≤0.015 to 16 | 0.3 | 0.5 | ≤0.015 | 0.5 | 8 |
| VRC | ≤0.015 to 8 | 0.5 | 0.5 | 0.5 | 0.5 | 4 |
| Matched C. glabrata isolates (n = 34)c | ||||||
| SCY-078 | 0.25–1 | 0.38 | 0.5 | 0.25 | 0.5 | 0.5 |
| FLC | 4–128 | 14 | 12 | 16 | 8 | 128 |
| ANF | ≤0.015 to 0.12 | 0.04 | 0.06 | 0.03 | 0.03 | 0.12 |
| MCF | ≤0.015 to 0.12 | 0.019 | ≤0.015 | ≤0.015 | ≤0.015 | 0.06 |
| CAS | ≤0.015 to 0.25 | 0.025 | ≤0.015 | ≤0.015 | ≤0.015 | 0.06 |
| VRC | 0.06–16 | 0.61 | 0.5 | 0.5 | 0.5 | 4 |
a
All drugs were tested with the Clinical and Laboratory Standards Institute broth microdilution method at concentrations ranging from 0.015 to 16 μg/ml, except for fluconazole, which ranged in concentration from 0.125 to 128 μg/ml. ANF, anidulafungin; CAS, caspofungin; FLC, fluconazole; MCF, micafungin; VRC, voriconazole.
b
C. glabrata isolates with known FKS1 or FKS2 mutations or phenotypic or clinical resistance (see the supplemental material).
c
C. glabrata isolates without known resistance, matched to the resistant isolates by year of recovery.