TABLE 2.
MIC results for 101 consecutive Candida isolates from unique episodes of bloodstream infection
Species and antifungal drug | MIC (μg/ml) |
|||||
---|---|---|---|---|---|---|
Rangea | Geometric mean | Median | Mode | MIC50 | MIC90 | |
C. albicans (n = 33) | ||||||
SCY-078 | 0.06–0.25 | 0.08 | 0.06 | 0.06 | 0.06 | 0.12 |
FLC | ≤0.125 to 128 | 1 | 0.5 | 0.25 | 0.5 | >128 |
ANF | ≤0.015 to 1 | 0.02 | ≤0.015 | ≤0.015 | ≤0.015 | 0.03 |
MCF | ≤0.015 to 1 | 0.02 | ≤0.015 | ≤0.015 | ≤0.015 | 0.06 |
CAS | ≤0.015 to 0.5 | 0.02 | ≤0.015 | ≤0.015 | ≤0.015 | 0.06 |
VRC | ≤0.015 to >16 | 0.08 | 0.03 | ≤0.015 | 0.03 | >16 |
C. albicans/dubliniensis not further identified (n = 5) | ||||||
SCY-078 | 0.12 | |||||
FLC | ≤0.125 to 0.25 | |||||
ANF | ≤0.125 to 0.03 | |||||
MCF | ≤0.015 to 0.03 | |||||
CAS | ≤0.015 to 0.03 | |||||
VRC | ≤0.015 | |||||
C. glabrata (n = 23) | ||||||
SCY-078 | 0.25–1 | 0.35 | 0.25 | 0.25 | 0.25 | 1 |
FLC | 2 to >128 | 11 | 8 | 8 | 8 | 64 |
ANF | 0.03–1 | 0.04 | 0.03 | 0.03 | 0.03 | 0.06 |
MCF | ≤0.015 to 0.5 | 0.02 | ≤0.015 | ≤0.015 | ≤0.015 | ≤0.015 |
CAS | ≤0.015 to 0.5 | 0.02 | ≤0.015 | ≤0.015 | ≤0.015 | 0.03 |
VRC | 0.03–8 | 0.3 | 0.25 | 0.25 | 0.25 | 1 |
C. krusei (n = 6) | ||||||
SCY-078 | 0.5–4 | |||||
FLC | 64–128 | |||||
ANF | 0.03–0.25 | |||||
MCF | 0.03–0.25 | |||||
CAS | 0.06–0.5 | |||||
VRC | 0.5–1 | |||||
C. parapsilosis (n = 18) | ||||||
SCY-078 | 0.25–0.5 | 0.26 | 0.25 | 0.25 | 0.25 | 0.25 |
FLC | 0.25–4 | 0.8 | 2 | 1 | 1 | 2 |
ANF | 0.06–2 | 0.92 | 1 | 1 | 1 | 2 |
MCF | 0.5–2 | 0.98 | 1 | 2 | 1 | 2 |
CAS | 0.06–0.5 | 0.22 | 0.25 | 0.25 | 0.25 | 0.5 |
VRC | ≤0.015 to 0.12 | 0.02 | 0.03 | 0.03 | 0.03 | 0.06 |
C. tropicalis (n = 12) | ||||||
SCY-078 | 0.03–0.5 | 0.1 | 0.12 | 0.12 | 0.12 | 0.25 |
FLC | 0.25–1 | 0.5 | 0.5 | 0.5 | 0.5 | 1 |
ANF | ≤0.015 | ≤0.015 | ≤0.015 | ≤0.015 | ≤0.015 | ≤0.015 |
MCF | ≤0.015 to 0.06 | 0.02 | ≤0.015 | ≤0.015 | ≤0.015 | 0.06 |
CAS | ≤0.015 to 0.06 | 0.01 | ≤0.015 | ≤0.015 | ≤0.015 | 0.03 |
VRC | ≤0.015 | 0.03 | 0.04 | 0.06 | 0.03 | 0.06 |
C lusitaniae (n = 3) | ||||||
SCY-078 | 1–2 | |||||
FLC | 0.5–2 | |||||
ANF | 0.12–0.25 | |||||
MCF | 0.12 | |||||
CAS | 0.12–0.25 | |||||
VRC | ≤0.015 |
Only ranges are reported when the number of isolates tested was less than 10.