TABLE 3.
Geometric mean TT anticoagulation parameters in arm A (RTV)a
| Parameter | AUEC0–24 (s · h) | TT24 (s) |
|---|---|---|
| Geometric mean value (% CV) | ||
| Phase 1 (DE alone) | 1,479 (20.7) | 28.6 (27.3) |
| Phase 2 (DE + RTV separated) | 1,320 (18.7) | 25.3 (17.8) |
| Phase 3 (DE + RTV simultaneously) | 1,424 (26.6) | 37.4 (27.6) |
| GMR (90% CI) for comparison of phases | ||
| Phase 2 vs phase 1 | 0.89 (0.79–1.00) | 0.88 (0.76–1.01) |
| Phase 3 vs phase 1 | 0.96 (0.82–1.11) | 1.31 (1.09–1.52)b |
a
AUEC0–24, area-under-the-time-effect curve from time zero to 24 h; DE, dabigatran etexilate; RTV, ritonavir; TT24, thrombin time at 24 h; CV, coefficient of variation; CI, confidence interval.
b
P < 0.05, based on a paired Student t test.