FIG 4.

Invasion-inhibitory activity of sulfated polysaccharides. Highly active HLMs and sulfated carbohydrates were tested in invasion inhibition assays to confirm their activity against merozoite invasion. All compounds were tested at 10 μg/ml. Data are expressed as the percent inhibition from one assay performed in duplicate relative to the inhibition caused by PBS as a reference control. Three CSC-negative controls were included in the assay, and all were noninhibitory (data not shown). †, prepared using pyridine sulfur trioxide complex; $, prepared using piperidine-N-sulfonic acid.