TABLE 3.
Inhibitory activity of heparin compounds of different sizes against merozoite invasion in growth inhibition assaysa
| Size group | Compound (size estimate [kDa]) | % inhibition (SEM) |
|---|---|---|
| Long chain | Mucosal heparin (>3–25) | 68 (7) |
| Lung heparin (>3–25) | 74 (5) | |
| Mucosal heparin of 5 kDa (>3–8) | 75 (4) | |
| Short chain | Mucosal heparin (3) | 37 (0) |
| Enoxaparin (3) | 64 (6) | |
| Bemiparin (3) | 45 (3) | |
| Fondaparinux (pentasaccharide) (3) | 34 (0) |
a
Heparin compounds of different oligosaccharide chain lengths at 100 μg/ml each were tested for inhibition of P. falciparum in growth inhibition assays. Data are the mean percent inhibition ± SEM from two assays performed in duplicate. Mucosal heparin is from a porcine source, and lung heparin is from a bovine source.