TABLE 1.
Activity of small molecules against M. bovis BCG and INH-susceptible and INH-resistant M. tuberculosis H37Rv and cytotoxicity against THP-1 macrophages
| Serial no. | NSC no. | MIC99 (μM) |
CC50 (μM) against THP-1 macrophages | ||
|---|---|---|---|---|---|
| M. bovis BCG | M. tuberculosis H37Rv | M. tuberculosis H37Rv INHr | |||
| 1 | NSC 18415 | 3.125 | 6.25 | 3.125 | >25 |
| 2 | NSC 122131 | 1.25 | 2.5 | NDa | ND |
| 3 | NSC 4263 | 1.56 | 1.56 | 3.125 | >25 |
| 4 | NSC 26371 | 1.56 | 25 | 25 | >25 |
| 5 | NSC 94945 | 0.78 | 1.56 | 1.56 | >25 |
| 6 | NSC 149286 | 1.56 | 1.56 | 3.125 | >25 |
| 7 | NSC 69187 | 1.56 | 3.125 | 3.125 | 5 |
| 8 | NSC 125531 | 1.56 | 3.125 | 1.56 | >25 |
| 9 | NSC 139021 | 1.56 | 3.125 | 3.125 | >25 |
| 10 | NSC 228155 | 0.78 | 1.56 | 1.56 | >25 |
| 11 | NSC 47147 | 6.25 | 3.125 | 6.25 | 5 |
| 12 | NSC 83318 | 0.39 | 12.5 | 12.5 | >25 |
| 13 | NSC 105827 | 0.78 | 1.56 | 3.125 | 5 |
| 14 | NSC 60339 | 1.56 | 3.125 | 3.125 | >25 |
| 15 | NSC 60340 | 0.39 | 3.125 | 3.125 | >25 |
| 16 | NSC 67436 | 6.25 | 25 | 25 | >25 |
| 17 | NSC 3852 | 6.25 | 12.5 | 12.5 | 5 |
| 18 | NSC 285166 | 3.125 | 12.5 | 12.5 | >25 |
| 19 | NSC 148958 | 6.25 | 50 | 25 | >25 |
| 20 | NSC 4280 | 6.25 | 6.25 | 3.125 | >25 |
| 21 | NSC 163501 | 0.78 | 0.39 | ND | >25 |
| 22 | NSC 659501 | 3.125 | 3.125 | 3.125 | >25 |
| 23 | NSC 697726 | 0.39 | 1.56 | 3.125 | 5 |
| 24 | NSC 328587 | 3.125 | 1.56 | 3.125 | 5 |
| 25 | NSC 82116 | 6.25 | 12.5 | 12.5 | >25 |
| 26 | NSC 693632 | 12.5 | 12.5 | 25 | >25 |
| 27 | NSC 687849 | 0.78 | 1.56 | 1.56 | >25 |
| 28 | NSC 273829 | 1.56 | 6.25 | 6.25 | >25 |
| 29 | NSC 183359 | 1.56 | 0.78 | ND | 5 |
| 30 | NSC 311153 | 1.56 | 1.56 | ND | >25 |
| 31 | NSC 641245 | 1.56 | 6.25 | ND | >25 |
| 32 | NSC 145366 | 1.56 | 1.56 | ND | 5 |
| 33 | NSC 690634 | 0.39 | 1.56 | 1.56 | 5 |
| 34 | NSC 218439 | 0.39 | 0.39 | 0.39 | >25 |
| 35 | NSC 10010 | 1.56–3.125 | 6.25 | 3.125 | 5 |
| 36 | INH | 0.39–0.78 | 0.39–0.78 | >50 | >25 |
a
ND, not done.