TABLE 2.
Effect of whiB7 deletion on the resistance profile of M. abscessus
| Antibiotic | MIC (mg/liter)a |
|||
|---|---|---|---|---|
| 0 mg/liter clarithromycin |
½ the MIC of clarithromycin |
|||
| WT | ΔwhiB7 mutant | WT | ΔwhiB7 mutant | |
| Amikacin | 3.1 | 0.8 | 12.5 | 0.8 |
| Tobramycin | 6.3 | 1.6 | 25 | 1.6 |
| Gentamicin | 6.3 | 1.6 | 25 | 1.6 |
| Sisomicin | 3.1 | 0.8 | 12.5 | 0.8 |
| Chloramphenicol | 100 | 25 | 100 | 25 |
| Tigecycline | 0.8 | 0.2 | 0.8 | 0.2 |
| Clarithromycin | 0.2 | 0.05 | 0.2 | 0.05 |
| Clarithromycinb | 3.1 | 0.1 | 25 | 0.4 |
a
Values are the medians of 3 experiments.
b
Clarithromycin resistance was also measured after 7 days of incubation, which is standard for macrolide MIC analysis.