TABLE 1.
Characteristics of the 153 patients included in the PK/TD analysis
| Patient parametera | Value(s) |
|---|---|
| Continuous variables [median (range)] | |
| Age (yrs) | 68 (19–101) |
| Wt (kg) | 60 (30–122) |
| Ht (cm) | 165 (140–193) |
| CLCR at baseline (ml/min/1.73 m2) | 63 (7–171) |
| APACHE II score | 20 (4–43) |
| Daily dose (mg colistin base activity) | 200 (75–600) |
| Duration of colistin therapy (days) | 9 (3–26) |
| Colistimethate Css,avg (mg/liter) | 4.58 (1.0–18.9) |
| Colistin Css,avg (mg/liter) | 2.20 (0.24–9.79) |
| Categorical variables (% of patients) | |
| Male sex | 66.0 |
| With comorbidity | |
| Malignancy | 18.5 |
| Neutropenia | 2.5 |
| Trauma | 16.7 |
| Hepatic disease | 4.9 |
| Diabetes | 26.5 |
| Transplant | 16.7 |
| Other potential nephrotoxin(s) | 23.5 |
a
Abbreviations: APACHE II, acute physiology and chronic health evaluation II; CLCR, creatinine clearance; Css,avg, average steady-state plasma concentration.