Table 1.
Demographics and clinical information of participants
Patient ID number | Diagnosis | Age (y) | Sex | Age at seizure onset (y) | Duration of epilepsy (y) | Seizure classification | Brain MRI finding | Site of CM DBS electrodes with optimal CR
|
Postoperative follow-up (months) | Mean seizure reduction (%) | |
---|---|---|---|---|---|---|---|---|---|---|---|
R | L | ||||||||||
P1 | LGS | 35 | M | 3 | 32 | Tonic, myoclonic, absence | Nonspecific | 2–/3+ | 2–/3+ | 18 | 26.8 |
P2 | LGS | 23 | M | 1 | 22 | Tonic, absence | Nonspecific | 2–/3+ | 2–/3+ | 24 | 52 |
P3 | LGS | 21 | F | 1 | 20 | Tonic, absence, GTCs | Nonspecific | 0–/3+ | 1–/3+ | 27 | 78.5 |
P4 | Multifocal (B F-PLE) | 26 | M | 23 | 3 | Focal to bilateral convulsive | Nonspecific | 2–/3+ | 1–/2+ | 6 | 99.2 |
P5 | Multifocal (B F-TLE) | 16 | F | 1 | 15 | Focal to bilateral convulsive | Nonspecific | 1–/2+ | 0–/1+ | 18 | 92.9 |
P6 | Multifocal (B TLE) | 35 | F | 16 | 19 | Focal to bilateral convulsive | Heterotopia, R tapetum | 1–/2+ | 2–/3+ | 15 | 92.2 |
P7 | Focal (R F-CLE) | 36 | F | 14 | 22 | Focal to bilateral convulsive | R schizencephaly, open lip | 1–/3+ | 1–/2+ | 27 | 58.5 |
P8 | Multifocal (R FLE/L C-PLE) | 31 | F | 12 | 19 | Focal to bilateral convulsive | R schizencephaly, closed lip | 2–/3+ | 2–/3+ | 27 | 76.8 |
P9 | Focal (L F-CLE) | 44 | M | 8 | 36 | Focal to bilateral convulsive | L schizencephaly, closed lip | 2–/1+ | 2–/3+ | 21 | 64.7 |
P10 | Multifocal (B FLE) | 39 | F | 30 | 9 | Focal to bilateral convulsive | Both schizencephaly, closed lip | 2–/3+ | 1–/3+ | 27 | 77.9 |
Note: Duration of epilepsy.
Abbreviations: B, bilateral; CM, centromedian thalamic nucleus; C-PLE, centro-parietal lobe epilepsy; CR, cortical recruiting response; DBS, deep brain stimulation; F, female; F-CLE, fronto-central lobe epilepsy; FLE, frontal lobe epilepsy; F-PLE, fronto-parietal lobe epilepsy; F-TLE, fronto-temporal lobe epilepsy; GTC, generalized tonic-clonic; L, left; LGS, Lennox–Gastaut syndrome; M, male; MRI, magnetic resonance imaging; R, right; TLE, temporal lobe epilepsy; y, years.