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. 2017 Oct 17;12:7627–7651. doi: 10.2147/IJN.S127549

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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AT-MNP therapy induced tumor cell apoptosis in tumor samples in vivo.

Notes: In A549 tumors, immunohistochemical analysis was used to calculate (A) p53 and (B) Bcl2 levels; quantification of positive p53 and Bcl2 cells shown. (C) Representative images of TUNEL-positive cells after different treatments and TUNEL levels from each group. In H1975-treated tumors, (D) p53 and (E) Bcl2 levels were detected through immunohistochemical assays; quantification of positive p53 and Bcl2 cells shown. (F) Representative images of TUNEL-positive cells from each group under different conditions and TUNEL levels after various treatments. Values are expressed as means ± standard error of mean. *P<0.05, **P<0.01, and ***P<0.001 vs Con group; ^#P<0.05; ^##P<0.01; ^###P<0.001. Analysis of variance and Dunnett’s analysis were included to compare the averages of multiple groups. The scale bars are all 25 μm.

Abbreviations: MNPs, magnetic nanoparticles; AT, actein; TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling; Con, control.