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. 2017 Oct 17;12:7627–7651. doi: 10.2147/IJN.S127549

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Fe₃O₄ MNP and AT combination showed no toxicity in vivo.

Notes: (A) Histological data of hematoxylin and eosin staining of livers from each group of mice without subcutaneous injection of A594 and H1975. The scale bar is 100 μm. Left: cell viability of normal liver cells of (B) L02 (from human), (C) AML12 (from mouse), and (D) BRL3A (from rat) were calculated after treatments with AT (0, 1, 2.5, 5, 10, 15, 20, 25, and 30 μM) and AT-MNPs (20 μg/mL; AT concentrations 0, 1, 2.5, 5, 10, 15, 20, 25, and 30 μM) for 24 hours. Right: cell viability of normal liver cells of (B) L02, (C) AML12, and (D) BRL3A were detected after treatments with AT (20 μM) and AT-MNPs (0, 2.5, 5, 10, 15, 20, 30 and 40 μg/mL; AT concentration of 20 μM) for 24 hours. Values are expressed as means ± standard error of mean.

Abbreviations: MNPs, magnetic nanoparticles; AT, actein.

Fe₃O₄ MNP and AT combination showed no toxicity in vivo.

Notes: (A) Histological data of hematoxylin and eosin staining of livers from each group of mice without subcutaneous injection of A594 and H1975. The scale bar is 100 μm. Left: cell viability of normal liver cells of (B) L02 (from human), (C) AML12 (from mouse), and (D) BRL3A (from rat) were calculated after treatments with AT (0, 1, 2.5, 5, 10, 15, 20, 25, and 30 μM) and AT-MNPs (20 μg/mL; AT concentrations 0, 1, 2.5, 5, 10, 15, 20, 25, and 30 μM) for 24 hours. Right: cell viability of normal liver cells of (B) L02, (C) AML12, and (D) BRL3A were detected after treatments with AT (20 μM) and AT-MNPs (0, 2.5, 5, 10, 15, 20, 30 and 40 μg/mL; AT concentration of 20 μM) for 24 hours. Values are expressed as means ± standard error of mean.

Abbreviations: MNPs, magnetic nanoparticles; AT, actein.