Table S2.

Univariable and multivariable analyses of recurrence-free survival in 307 patients with hepatocellular carcinoma

Variable	n	Recurrence-free survival (%)			Univariable P#	Multivariable P*	Hazard ratio
		1 year	3 years	5 years
Sex
Male	278	53.5	36.3	33.1	0.566
Female	29	58.2	45.8	38.8
Age (years)
<60	255	52.7	37.4	34.0	0.778
≥60	52	59.8	36.3	31.7
Presentation
Subclinical	159	80.1	59.5	43.5	<0.001	0.095
Symptomatic	148	65.4	44.3	29.0
HBsAg
Positive	263	52.1	35.4	32.0	0.139
Negative	44	63.2	45.6	42.1
TB (µmol/L)
<18.8	192	49.1	30.3	28.6	0.157
≥18.8	115	56.8	41.1	36.7
α-Fetoprotein (mg/L)
<400	145	66.6	45.0	40.2	<0.001	0.026	1.45 (1.04, 2.01)
≥400	162	41.4	29.8	27.7
PT (s)
<13	149	56.4	39.4	36.3	0.580
≥13	158	51.9	36.2	31.5
Child–Pugh grade
A	295	54.1	37.0	33.4	0.738
B	12	48.6	30.2	20.2
Cirrhosis
Yes	202	51.4	35.8	32.2	0.740
No	105	58.7	38.4	35.0
ALT (units/L)
<40	133	54.9	39.5	34.2	0.899
≥40	174	52.6	35.5	33.7
AST (units/L)
<40	103	65.9	46.0	40.5	0.029	0.326
≥40	204	54.3	34.8	30.5
Spontaneous tumor rupture
Yes	106	45.8	34.2	31.3	0.016	0.782	0.95 (0.64, 1.41)
No	201	58.2	39.7	36.0
Maximum tumor size (cm)
<5	103	78.1	52.4	50.1	<0.001	0.001	1.99 (1.35, 2.93)
≥5	204	40.6	29.8	24.4
Macroscopic vascular invasion
Yes	124	55.1	34.6	2	0.664
No	183	53.1	32.9	45
Microscopic vascular invasion
Yes	270	10.4	10.1	6.9	<0.001	0.002	2.01 (1.29, 3.12)
No	37	59.2	40.5	37.1
Extrahepatic spread
Yes	68	35.7	27.0	19.2	<0.001	0.064
No	239	58.9	40.1	37.6
Tumor differentiation
I–II	50	85.0	72.0	67.0	<0.001	0.511
III–IV	257	66.0	44.2	35.4
Tumor type
Unifocal	242	58.8	40.9	37.0	<0.001	0.661
Multiple/diffuse	65	35.5	23.7	21.7
Perioperative blood loss (mL)
<500	209	75.2	56.0	46.0	<0.001	0.165
≥500	98	58.0	34.5	28.7
Intraoperative blood transfusion
Yes	76	53.0	30.2	22.5	<0.001	0.057
No	231	74.5	54.9	45.4
Type of hepatectomy
Anatomical	189	68.8	49.4	40.2	0.899
Non-anatomical	118	68.6	48.9	40.8
Extent of hepatectomy
Major	163	61.9	44.0	31.0	0.079
Minor	144	70.5	50.9	41.6

Notes: Values in parentheses are 95% confidence intervals.

^#Log rank test.

^*Variables with univariable P<0.05 were entered in the Cox regression model.

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; PT, prothrombin time; TB, total bilirubin.