Table S1.
Univariable and multivariable analyses of overall survival in 307 patients with hepatocellular carcinoma
| Variable | n | Overall survival (%)
|
Univariable P# | Multivariable P* | Hazard ratio | ||
|---|---|---|---|---|---|---|---|
| 1 year | 3 years | 5 years | |||||
| Sex | |||||||
| Male | 278 | 63.4 | 43.3 | 31.7 | 0.403 | ||
| Female | 29 | 69.0 | 51.7 | 37.9 | |||
| Age (years) | |||||||
| <60 | 255 | 62.4 | 42.3 | 33.8 | 0.929 | ||
| ≥60 | 52 | 71.7 | 52.8 | 25.0 | |||
| Presentation | |||||||
| Subclinical | 149 | 87.9 | 66.0 | 54.9 | 0.016 | 0.184 | |
| Symptomatic | 158 | 79.2 | 48.5 | 39.7 | |||
| HBsAg | |||||||
| Positive | 263 | 62.7 | 42.2 | 30.2 | 0.062 | ||
| Negative | 44 | 70.5 | 54.4 | 43.1 | |||
| TB (µmol/L) | |||||||
| <18.8 | 192 | 68.2 | 49.0 | 37.7 | 0.007 | 0.871 | |
| ≥18.8 | 115 | 56.9 | 36.0 | 23.0 | |||
| α-Fetoprotein (mg/L) | |||||||
| <400 | 146 | 80.8 | 58.8 | 43.9 | <0.001 | 0.002 | 1.59 (1.18, 2.15) |
| ≥400 | 161 | 48.8 | 30.9 | 22.0 | |||
| PT (s) | |||||||
| <13 | 149 | 63.1 | 40.3 | 31.8 | 0.938 | ||
| ≥13 | 158 | 64.8 | 47.7 | 32.7 | |||
| Child–Pugh grade | |||||||
| A | 295 | 64.9 | 44.5 | 32.3 | <0.001 | 0.044 | 0.43 (0.19, 0.98) |
| B | 12 | 41.7 | 33.3 | 27.5 | |||
| Cirrhosis | |||||||
| Yes | 105 | 67.6 | 48.6 | 34.9 | 0.385 | ||
| No | 202 | 62.1 | 41.8 | 31.0 | |||
| ALT (units/L) | |||||||
| <40 | 133 | 60.9 | 47.3 | 35.4 | 0.387 | ||
| ≥40 | 174 | 66.3 | 41.7 | 30.0 | |||
| AST (units/L) | |||||||
| <40 | 103 | 73.8 | 56.2 | 44.8 | 0.008 | 0.326 | |
| ≥40 | 204 | 59.0 | 38.0 | 26.0 | |||
| Spontaneous tumor rupture | |||||||
| Yes | 106 | 37.7 | 19.7 | 14.7 | <0.001 | <0.001 | 1.89 (1.32, 2.69) |
| No | 201 | 77.7 | 56.9 | 41.6 | |||
| Maximum tumor size (cm) | |||||||
| <5 | 103 | 88.3 | 67.9 | 52.9 | <0.001 | 0.003 | 1.74 (1.21, 2.49) |
| ≥5 | 204 | 51.7 | 32.2 | 21.9 | |||
| Macroscopic vascular invasion | |||||||
| Yes | 125 | 45.2 | 12.9 | 5.7 | <0.001 | 0.806 | |
| No | 182 | 64.5 | 45.8 | 35.7 | |||
| Microscopic vascular invasion | |||||||
| Yes | 272 | 27.8 | 11.1 | 8.3 | <0.001 | <0.001 | 2.30 (1.53, 3.46) |
| No | 35 | 68.7 | 48.5 | 35.5 | |||
| Extrahepatic spread | |||||||
| Yes | 67 | 41.2 | 26.5 | 20.6 | <0.001 | 0.155 | |
| No | 240 | 70.4 | 49.1 | 35.7 | |||
| Tumor differentiation | |||||||
| I–II | 45 | 92.5 | 77.0 | 66.9 | <0.001 | 0.080 | |
| III–IV | 262 | 79.7 | 53.1 | 43.3 | |||
| Tumor type | |||||||
| Unifocal | 242 | 70.2 | 50.4 | 36.6 | <0.001 | 0.002 | 1.69 (1.22, 2.36) |
| Multiple/diffuse | 65 | 40.9 | 21.2 | 16.4 | |||
| Blood loss (mL) | |||||||
| <500 | 200 | 86.5 | 65.9 | 56.2 | 0.004 | 0.084 | |
| ≥500 | 107 | 72.0 | 40.0 | 29.0 | |||
| Blood transfusion | |||||||
| Yes | 83 | 66.7 | 34.0 | 23.2 | <0.001 | 0.221 | |
| No | 224 | 87.8 | 65.6 | 55.9 | |||
| Type of hepatectomy | |||||||
| Anatomical | 189 | 82.4 | 57.5 | 47.0 | 0.600 | ||
| Non-anatomical | 118 | 81.1 | 54.9 | 46.0 | |||
| Extent of hepatectomy | |||||||
| Major | 163 | 80.0 | 54.8 | 44.2 | 0.130 | ||
| Minor | 144 | 85.1 | 60.0 | 47.3 | |||
| Surgical resection margin | |||||||
| R0 | 265 | 88.8 | 64.6 | 53.7 | <0.001 | 0.057 | |
| R1 | 40 | 43.8 | 9.8 | 5.8 | |||
| R2 | 2 | 18.9 | 4.9 | 2.0 | |||
Notes: Values in parentheses are 95% confidence intervals.
#
Log rank test.
*
Variables with univariable P<0.05 were entered in the Cox regression model.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; PT, prothrombin time; TB, total bilirubin.