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. 2017 Oct 17;12:3029–3039. doi: 10.2147/COPD.S147144

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© 2017 He et al. This work is published and licensed by Dove Medical Press Limited

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Two continuous section-contrasted IHS of lung tissue of the model group and control group mice (400× magnification).

Notes: (A, E, I, M and Q) show the located label of M2 macrophages (CD206) in the control group and (C, G, K, O and S) that in the model group. (B, F, J, N and R) show the target proteins in the control group and (D, H, L, P and T) those in the model group. (B and D) show TGF-β. (F and H) show TGF-βRII. (J and L) show p-Smad2. (N and P) show p-Smad3. (R and T) show Smad7. (U) shows the negative control group. Indicating, in the model group, the percentage of double-positive/CD206-positive cells are all higher than those of the corresponding control group (double positive cells are marked by black arrows in model groups).

Abbreviation: IHS, immunohistochemical staining.