Table 1. Canine glioma patients treated with PAC-1, TMZ and ionizing radiationa.

					Change in Tumor Burden Following Treatment
Patient	Breed	Age	Sex	PAC-1 dosage (mg/kg)	PAC-1 monotherapy	Combination therapy
1	Labrador retriever	7	FSa	12.5b	↓ 6%	↓ 100%
2	Dachshund	8	FS	10.0	↓ 5%	↓ 43%
3	Boxer	5	FS	7.5	↑ 19%	↓ 60%

^aAbbreviations: FS; spayed female. ^bPAC-1 dosage was 12.5 mg/kg for days 1-56, then reduced to 8.0 mg/kg for days 57-84.