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. 2017 Sep 16;8(46):80139–80155. doi: 10.18632/oncotarget.20960

Figure 1. TRF2/Terc double null mutant mice exhibit features of stem cell depletion in epidermis.

Figure 1

A. TRF2 mRNA and Terc RNA expression in K14Cre;TRF2+/+;Terc+/+, K14Cre;TRF2f/f;Terc+/+, K14Cre;TRF2+/+;Terc-/-, and K14Cre;TRF2f/f;Terc-/- epidermis is shown by qRT-PCR. Error bars represent SEM. B. Telomerase activity in epidermis from the indicated genotypes is shown by TRAP assay. Internal amplification controls are shown. A representative gel is shown. C. TRF2 protein expression in epidermis from the indicated genotypes is shown by western blot. β-actin expression is shown as the gel loading control for each lane. Representative blots are shown. D.-G. TRF2/Terc double null mutant mice exhibit a phenotype similar to the crinkled mouse. Representative photographs of mouse tails from the indicated genoptypes are shown. H.-K. Skin histopathology of the indicated genotypes is shown by H&E staining. Scale bar = 10 μm. Representative photomicrographs are shown.