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(A) Timeline of tamoxifen administration, castration, and sacrifice of control and experimental mice; and (B) representative images of prostate tissue from ApcfloxSmad4flox, ApccKO, and ApccKOSmad4cKO mice were stained for hematoxylin and eosin (H&E) and immuno-stained for beta-catenin and Ki67. Scale bars = 100 μm.
