Table 3. Adverse events occurring at any grade in the study subjects (n = 50).

	All grades, no. (%)	Grade ≥ 3, no. (%)
Hematologic
Leukopenia	46 (92)	23 (46)
Neutropenia	39 (78)	23 (46)
Anemia	50 (100)	3 (6)
Thrombocytopenia	33 (66)	2 (4)
Febrile neutropenia	5 (10)	5 (10)
Nonhematologic
Anorexia	26 (52)	2 (4)
Constipation	33 (66)	0 (0)
Mucosal inflammation	21 (42)	0 (0)
Esophagitis	31 (62)	0 (0)
Fatigue	24 (48)	2 (4)
Nausea	27 (54)	2 (4)
Vomiting	9 (18)	0 (0)
Diarrhea	5 (10)	0 (0)
Pyrexia	14 (28)	0 (0)
Elevated AST	12 (24)	0 (0)
Elevated ALT	18 (36)	0 (0)
Increased total bilirubin	9 (18)	0 (0)
Increased creatinine	17 (34)	2 (4)
Hyperkalemia	29 (58)	1 (2)
Hyponatremia	31 (62)	8 (16)
Pneumonitis	8 (16)	1 (2)
Esophageal perforation	3 (6)	3 (6)
Pericardial effusion	6 (12)	0 (0)

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase.