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. 2017 Sep 7;8(46):80315–80324. doi: 10.18632/oncotarget.20699

Figure 3. Vinpocetine inhibited the activation of the TLR4/MyD88 /NF-κB pathway in mice with cerebral ischemia reperfusion injury.

Figure 3

A. After cerebral ischemia/reperfusion injury, TLR4 expression was increased significantly in the infarcted area 24 h after the induction of ischemia and reperfusion. B. The levels of TLR4, MyD88, TRIF, and total and nuclear NF-kB p65 proteins were examined by Western blotting. The vinpocetine treatment inhibited the increase in TLR4 C. and MyD88 D. expression, but not TRIF E. (n = 5). Total NF-κB p65 F. and nuclear NF-κB p65 G., H. expression are shown. Data are presented as means±SEM (**p < 0.01).