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. 2017 Jul 5;8(46):80416–80428. doi: 10.18632/oncotarget.19010

Table 2. Genes mutated in more than half of the osteosarcoma patients and their biological functions.

Biological function Mutated genes
Transcription regulation ATF2; BPTF; CHD7; DENND4A; HIVEP2; IKBKAP; JMJD1C; KMT2C; KMT2E; MYCBP2; NCOR1; RFX7; SPEN;
Transport ABCB5; ABCD2; ANKH; ATP10D; CACNA2D3; DGKD; HERC1; ITPR1; SLC8A1; SLC9B1; TRPM3;
Cell Adhesion DST; FN1; ITGA6; MPDZ; NRXN2; RELN;
Immunity C5; CFH; PKHD1L1;
Apoptosis BIRC6; ITPR1; KIF1B;
Endocytosis DGKD; LRP2; STAB2;
Cell cycle ALMS1; ATM; BIRC6; KMT2E;
DNA damage ATF2; ATM; DNA2; POLQ; PRDM10; PSME4;
Angiogenesis FN1; THSD7A;
Ubl conjugation pathway BIRC6; HECTD1; HERC1; MYCBP2;
Wnt signaling pathway MACF1;
Differentiation ABCB5; OBSCN; PSME4; THSD7A;
DNA repair DNA2; POLQ; PRDM10; PSME4;
Muscle development DMD; NEB; SYNE1; UTRN;
Regulation of bone mineralization ENPP1; FBN2;
Cell communication FRAS1;
mRNA processing FRG1;
Nucleotide metabolism NT5C2;
Multicellular organism development PRTG;
Regulation of cell migration SYNE2;
Small GTPase mediated signal trasduction DOCK5;
Regulation of GTPase activity AKAP13; DENND4A; PREX2; SYDE2;
Extracellular matrix organization EGFLAM;
Microtuble-based movement DNAH9; DNAH10;