Table 6. Mutated genes in non-responder group of osteosarcoma patients and their chromosomal location and biological process.
| Gene | Chromosomal location | Biological process |
|---|---|---|
| ALDH1L2 | 12q23.3 | Metabolism of cofactors and vitamins |
| BCLAF1 | 6q23.3 | Spliceosome |
| CLCN1 | 7q34 | Ion channels |
| COG3 | 13q14.13 | Membrane trafficking |
| DIS3 | 13q22.1 | mRNA biogenesis |
| ERBB4 | 2q34 | Signal trasduction, Transport and catabolism, Human disease |
| KARS | 16q23.1 | tRNA biogenesis |
| OR52N1 | 11p15.4 | Olfactory transduction |
| PDE6C | 10q24 | Sensory transduction |
| PDHX | 11p13 | Carbohydrate metabolism |
| SCN8A | 12q13 | Ion channels |
| SP140L | 2q37.1 | unknown |
| THBS1 | 15q15 | Signal trasduction, Transport and catabolism, Human disease, Cell growth and death |
| UBE4A | 11q23.3 | Ubiquitin mediated proteolysis |
| ZNF12 | 7p22.1 | Transcription factors |