Table 2. The 41 SNPs significantly (P < 1.21 × 10−6) associated with FPG level in the EWAS.
| Gene | dbSNP | Nucleotide (amino acid) substitutiona | Chromosome: position | MAF (%) | P (genotype) |
|---|---|---|---|---|---|
| OR4F6 | rs141569282 | G/A (A117T) | 15: 101806068 | 1.7 | 1.07 × 10−12 |
| SLC35F3 | rs140011243 | T/G (C144G) | 1: 234231563 | 0.5 | 1.56 × 10−11 |
| RUFY1 | rs138313632 | T/G (S705A) | 5: 179609505 | 0.5 | 9.91 × 10−11 |
| KARS | rs201151665 | A/T (M29L) | 16: 75647967 | 0.4 | 3.98 × 10−10 |
| IFITM5 | rs146230729 | G/T (P31T) | 11: 299400 | 0.5 | 6.30 × 10−10 |
| CADM1 | rs561567580 | G/C (R7P) | 11: 115504375 | 0.4 | 6.76 × 10−10 |
| PPP1R9B | rs113281588 | G/C (G311A) | 17: 50149582 | 0.5 | 1.57 × 10−9 |
| MUC17 | rs78010183 | A/T (T1305S) | 7: 101035329 | 1.8 | 1.63 × 10−9 |
| CCDC166 | rs75368383 | T/C (K187R) | 8: 143707454 | 0.5 | 1.70 × 10−9 |
| SCAMP4 | rs150715312 | A/G (K69E) | 19: 1912252 | 0.6 | 1.74 × 10−9 |
| PLEC | rs201654895 | A/G (M3874V) | 8: 143918282 | 0.4 | 2.21 × 10−9 |
| LGR5 | rs117324318 | G/A | 12: 71440257 | 0.4 | 2.68 × 10−9 |
| CCDC114 | rs140189114 | C/T (G632R) | 19: 48297095 | 0.4 | 3.82 × 10−9 |
| NLRC3 | rs116433328 | G/C (M286I) | 16: 3564079 | 0.4 | 6.74 × 10−9 |
| CECR2 | rs201989565 | G/A | 22: 17548704 | 0.4 | 1.12 × 10−8 |
| DUS2 | rs202069030 | G/C (R51S) | 16: 68023050 | 0.4 | 1.14 × 10−8 |
| SIGLEC1 | rs201950990 | A/C (V69G) | 20: 3706550 | 0.5 | 2.11 × 10−8 |
| ALKBH1 | rs200168197 | A/C (V329G) | 14: 77673996 | 0.4 | 2.72 × 10−8 |
| TNFRSF4 | rs150516264 | A/G (L98P) | 1: 1213069 | 0.4 | 2.95 × 10−8 |
| LOC100505549 | rs139012426 | G/C (S1242T) | 18: 57648519 | 0.4 | 3.64 × 10−8 |
| ADAD2 | rs149894736 | C/T (P107L) | 16: 84191550 | 0.7 | 3.70 × 10−8 |
| YBEY | rs200145138 | C/G (L148V) | 21: 46297572 | 0.4 | 3.84 × 10−8 |
| PRKCDBP | rs11544766 | C/G (T68S) | 11: 6320274 | 0.4 | 5.38 × 10−8 |
| MYLIP | rs201021082 | T/C (V17A) | 6: 16129372 | 0.4 | 5.47 × 10−8 |
| MGAT3 | rs201417286 | T/G (V200G) | 22: 39487946 | 0.3 | 6.54 × 10−8 |
| B3GNT6 | rs559157215 | A/G (H301R) | 11: 77040453 | 0.3 | 7.38 × 10−8 |
| KNDC1 | rs146093427 | A/G (N546D) | 10: 133195723 | 0.4 | 8.57 × 10−8 |
| TNXB | rs141190850 | T/C (D677G) | 6: 32095823 | 0.3 | 8.62 × 10−8 |
| PCDHAC1 | rs185216314 | A/G (Q479R) | 5: 140968202 | 0.1 | 1.40 × 10−7 |
| CSPG4 | rs137981794 | T/C (D1936G) | 15: 75676712 | 0.4 | 1.50 × 10−7 |
| DNAJB2 | rs148615702 | C/G (Q235E) | 2: 219284715 | 0.3 | 1.63 × 10−7 |
| FGD3 | rs116496123 | G/T | 9: 93034624 | 0.7 | 1.71× 10−7 |
| AK8 | rs150636539 | G/A (P328S) | 9: 132792773 | 0.3 | 2.04 × 10−7 |
| LAMB3 | rs202068754 | A/C (V753G) | 1: 209623605 | 0.4 | 2.06 × 10−7 |
| GDPD3 | rs200801803 | G/A | 16: 30112132 | 0.3 | 2.95 × 10−7 |
| CAT | rs139421991 | G/A (R320Q) | 11: 34456720 | 0.3 | 3.01 × 10−7 |
| OAS3 | rs62623451 | G/A (A49T) | 12: 112938675 | 0.3 | 3.13 × 10−7 |
| NOTCH1 | rs201053795 | T/C (T970A) | 9: 136509794 | 0.6 | 3.43 × 10−7 |
| PDCL2 | rs189305583 | C/T (V69I) | 4: 55580834 | 0.1 | 4.24 × 10−7 |
| SYNM | rs200549249 | G/A (G235E) | 15: 99105903 | 0.2 | 7.54 × 10−7 |
| SNTB1 | rs145615160 | A/G (Y57H) | 8: 120811675 | 0.5 | 1.09 × 10−6 |
The relation of genotypes of SNPs to FPG level was examined by linear regression analysis. aMajor allele/minor allele.