Table 3. The 17 SNPs significantly (P < 1.21 × 10−6) associated with blood HbA1c content in the EWAS.
| Gene | dbSNP | Nucleotide (amino acid) substitutiona | Chromosome: position | MAF (%) | P (genotype) |
|---|---|---|---|---|---|
| PTCHD3 | rs77473776 | T/G (Q186K) | 10: 27413695 | 30.6 | 3.59 × 10−38 |
| C21orf59 | rs76974938 | C/T (D67N) | 21: 32609946 | 2.4 | 1.68 × 10−27 |
| TNC | rs138406927 | C/T (A1096T) | 9: 115064848 | 2.1 | 4.60 × 10−27 |
| KRR1 | rs17115182 | G/A (P43S) | 12: 75508405 | 7 | 5.17 × 10−22 |
| ZNF43 | rs149604219 | G/A (A93V) | 19: 21809741 | 3 | 7.87 × 10−17 |
| PRCP | rs2229437 | T/G (E133D) | 11: 82853252 | 6.4 | 9.82 × 10−12 |
| CYP4F12 | rs609636 | G/A (D76N) | 19: 15678288 | 2.3 | 4.74 × 10−11 |
| rs1917321 | A/C | 11: 49356208 | 35.5 | 3.33 × 10−10 | |
| LGALS14 | rs72480733 | G/A (R27H) | 19: 39705987 | 36.7 | 2.19 × 10−8 |
| ANKRD26 | rs12572862 | C/G (L1219V) | 10: 27033374 | 21.7 | 1.35 × 10−7 |
| CAT | rs139421991 | G/A (R320Q) | 11: 34456720 | 0.3 | 1.69 × 10−7 |
| ZKSCAN3 | rs13201752 | A/G (K200E) | 6: 28363350 | 36.5 | 2.60 × 10−7 |
| rs10451497 | C/T | 19: 15093055 | 31.2 | 5.29 × 10−7 | |
| OR8H3 | rs61751933 | C/T (T16M) | 11: 56122419 | 18.3 | 7.54 × 10−7 |
| PDCL2 | rs189305583 | C/T (V69I) | 4: 55580834 | 0.1 | 8.56 × 10−7 |
| HIVEP1 | rs200286173 | A/G (Y374C) | 6: 12120916 | 0.2 | 9.93 × 10−7 |
| RSL24D1 | rs200023487 | A/G (V28A) | 15: 55192832 | 0.1 | 1.20 × 10−6 |
The relation of genotypes of SNPs to blood HbA1c content was examined by linear regression analysis. aMajor allele/minor allele.