Table 3. The diagnostic performance of four markers and ANN models for all stages HCC and early stage HCC cases in cirrhotic patients.

Markers	HCC vs LC					Early HCC vs LC
	AUC	p Value	Cut-off	Sensitivity	Specificity	AUC	p Value	Cut-off	Sensitivity	Specificity
AFP(ng/mL)	0.713(0.659-0.767)	<0.001	49.4	0.564	0.822	0.650(0.575-0.725)	<0.001	43.7	0.469	0.809
GP73(ng/mL)	0.618(0.559-0.677)	<0.001	148.6	0.921	0.344	0.703(0.630-0.776)	<0.001	181.4	0.770	0.593
AFP-L3(ng/mL)	0.730(0.678-0.782)	<0.001	8.028	0.523	0.895	0.672(0.597-0.748)	<0.001	3.813	0.494	0.842
DCP(mAU/mL)	0.764(0.714-0.814)	<0.001	28.1	0.621	0.855	0.609(0.527-0.690)	0.006	13.7	0.605	0.645
MLP-Models	0.753(0.701-0.806)	<0.001	0.5	0.697	0.809	0.692(0.616-0.768)	<0.001	0.5	0.469	0.914
RBF-Models	0.742(0.688-0.795)	<0.001	0.5	0.733	0.750	0.659(0.582-0.735)	<0.001	0.5	0.481	0.836