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. 2017 Jul 26;8(46):80568–80588. doi: 10.18632/oncotarget.19631

Figure 3. NO induces increased EGFR and ERK phosphorylation in TNBC cell lines.

Figure 3

Phosphorylation status of EGFR (A) in the MCF-10A, MDA-MB-468 and HCC1806 cell lines after 24 hours exposure to increasing doses of DETA/NO alone or in combination with 100nM of PD153035 (EGFR inhibitor). (B) Phosphorylation status of the MAP kinases ERK1 and ERK2 after 24 hours exposure to 0.5mM of DETA/NO alone or in combination with 100nM of PD153035 or 200nM PD198306 (MEK inhibitor).