Table 2. Association of iNOS with TNBC outcomes.
Univariate Cox Regression Analysis | ||||
---|---|---|---|---|
HR | 95% Confidence Interval | P-value | ||
iNOS Levels & Disease Free Survival* | ||||
Negative | 1.0 | 27 | ||
Low | 3.5 | 1.04-11.53 | 0.042 | 79 |
Moderate | 4.4 | 1.31-14.74 | 0.017 | 59 |
High | 3.0 | 0.82-10.75 | 0.095 | 34 |
iNOS Levels & Metastasis Free Survival* | ||||
Negative | 1.0 | 27 | ||
Low | 8.0 | 1.06-59.75 | 0.043 | 79 |
Moderate | 12.1 | 1.61-90.06 | 0.015 | 59 |
High | 6.5 | 0.80-51.89 | 0.080 | 34 |
iNOS Levels & Breast Cancer Specific Survival | ||||
Negative | 1.0 | 28 | ||
Low | 5.2 | 1.21-22.15 | 0.026 | 78 |
Moderate | 6.0 | 1.38-25.70 | 0.017 | 59 |
High | 3.5 | 0.74-16.55 | 0.112 | 35 |
Multivariable Cox Regression Analysis** | ||||
HR | 95% Confidence Interval | P-value | N | |
iNOS Levels & Disease Free Survival | ||||
Negative | 1.0 | 27 | ||
Low | 3.5 | 1.04-11.51 | 0.044 | 79 |
Moderate | 4.6 | 1.35-15.79 | 0.015 | 59 |
High | 2.8 | 0.75-10.12 | 0.127 | 33 |
iNOS Levels & Metastasis Free Survival | ||||
Negative | 1.0 | 27 | ||
Low | 7.9 | 1.05-59.49 | 0.044 | 79 |
Moderate | 12.7 | 1.67-95.91 | 0.014 | 59 |
High | 6.1 | 0.75-49.76 | 0.091 | 34 |
iNOS Levels & Breast Cancer Specific Survival | ||||
Negative | 1.0 | 28 | ||
Low | 5.3 | 1.24-22.90 | 0.024 | 78 |
Moderate | 6.2 | 1.43-27.13 | 0.026 | 59 |
High | 3.2 | 0.67-15.15 | 0.142 | 34 |
*Adjusted for age at diagnosis, no chemotherapy/neoadjuvant/adjuvant chemotherapy/unknown, tumor grade, histological subtype.