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. 2017 Jul 26;8(46):80568–80588. doi: 10.18632/oncotarget.19631

Table 2. Association of iNOS with TNBC outcomes.

Univariate Cox Regression Analysis
HR 95% Confidence Interval P-value
iNOS Levels & Disease Free Survival*
Negative 1.0 27
Low 3.5 1.04-11.53 0.042 79
Moderate 4.4 1.31-14.74 0.017 59
High 3.0 0.82-10.75 0.095 34
iNOS Levels & Metastasis Free Survival*
Negative 1.0 27
Low 8.0 1.06-59.75 0.043 79
Moderate 12.1 1.61-90.06 0.015 59
High 6.5 0.80-51.89 0.080 34
iNOS Levels & Breast Cancer Specific Survival
Negative 1.0 28
Low 5.2 1.21-22.15 0.026 78
Moderate 6.0 1.38-25.70 0.017 59
High 3.5 0.74-16.55 0.112 35
Multivariable Cox Regression Analysis**
HR 95% Confidence Interval P-value N
iNOS Levels & Disease Free Survival
Negative 1.0 27
Low 3.5 1.04-11.51 0.044 79
Moderate 4.6 1.35-15.79 0.015 59
High 2.8 0.75-10.12 0.127 33
iNOS Levels & Metastasis Free Survival
Negative 1.0 27
Low 7.9 1.05-59.49 0.044 79
Moderate 12.7 1.67-95.91 0.014 59
High 6.1 0.75-49.76 0.091 34
iNOS Levels & Breast Cancer Specific Survival
Negative 1.0 28
Low 5.3 1.24-22.90 0.024 78
Moderate 6.2 1.43-27.13 0.026 59
High 3.2 0.67-15.15 0.142 34

*Adjusted for age at diagnosis, no chemotherapy/neoadjuvant/adjuvant chemotherapy/unknown, tumor grade, histological subtype.