Table 5. Serum uric acid* and hyperuricemia as a risk for incident CAD events in the subjects.

	Crude			Model 1			Model 2			Model 3
	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Total = 2142
Hyperuricemia	1.84	1.41–2.49	< 0.001	1.81	1.40–2.42	< 0.001	1.77	1.39–2.49	< 0.001	1.73	1.27–2.31	0.001
Per SUA 1mg/dL	1.19	1.12–1.26	< 0.001	1.16	1.10–1.23	< 0.001	1.13	1.11–1.24	0.001	1.11	1.05–1.20	0.001
Male sex = 1194
Hyperuricemia	1.81	1.31–2.61	< 0.001	1.79	1.33–2.59	< 0.001	1.75	1.30–2.4	< 0.001	1.68	1.13–1.89	0.010
Per SUA 1mg/dL	1.20	1.10–1.26	< 0.001	1.18	1.09–1.25	< 0.001	1.15	1.06–1.29	< 0.001	1.12	1.03–1.24	0.038
Female sex = 948
Hyperuricemia	1.86	1.25–2.60	0.001	1.84	1.26–2.65	0.002	1.80	1.26–2.66	0.019	1.75	1.24–2.67	0.019
Per SUA 1mg/dL	1.15	1.10–1.27	< 0.001	1.14	1.10–1.28	< 0.001	1.12	1.08–1.29	< 0.001	1.10	1.05–1.30	0.001

*SUA indicated serum uric acid level of ending of study.

Model 1: Data adjusted for age, sex, smoking and drinking habits at the end of study.

Model 2: Data adjusted for baseline age, sex, smoking and drinking habits, baseline BMI, baseline systolic BP and diastolic BP at the end of study.

Model 3: Data adjusted for baseline age, sex, smoking and drinking habits, baseline BMI, baseline systolic BP and diastolic BP, and baseline eGFR, total-cholesterol, triglycerides, LDL and HDL at the end of study.

CAD = coronary artery disease; BMI = body mass index; BP = blood pressure; eGFR = estimated glomerular filtration rate; SUA = serum uric acid; LDL = low density lipoprotein; HDL = high density lipoprotein; HR = hazards ratio; CI = confidence interval.