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(A) Volume change of MCF-7 spheroids treated with blank particle, free (DOX + PTX), DOX/MCD + free PTX, F3 or F6 (at 100 ng/mL DOX and 20 ng/mL PTX) up to 21 days. (B) A close-up of growth curve of spheroids treated with free (DOX + PTX), DOX/MCD + free PTX, F3 or F6. (C) Viability of spheroids assessed by the acid phosphatase assay at the end of study (n=3, mean ±SD).
