Table 2. The basic information of the genotyped polymorphisms in four SNPs in the CCND1 associated with the RCC risk.
| Polymorphisms | Cases (n = 1488) | Controls (n = 1677) | P* | Adjusted OR (95% CI)* | ||
|---|---|---|---|---|---|---|
| N | % | N | % | |||
| rs1944129 | ||||||
| AA | 824 | 55.4 | 992 | 59.2 | 0.015 | 1.00 (reference) |
| AG | 557 | 37.4 | 600 | 35.8 | 0.145 | 1.12(0.96-1.30) |
| GG | 107 | 7.2 | 85 | 5.1 | 0.005 | 1.56(1.15-2.13) |
| AG+GG | 664 | 44.6 | 685 | 40.8 | 0.032 | 1.17(1.01-1.35) |
| A allele | 2205 | 74.1 | 2584 | 77.0 | 0.006 | |
| G allele | 771 | 25.9 | 770 | 23.0 | ||
| rs7177 | ||||||
| AA | 1025 | 68.9 | 1205 | 71.9 | 0.018 | 1.00 (reference) |
| AC | 423 | 28.4 | 448 | 26.7 | 0.117 | 1.14(0.97-1.33) |
| CC | 40 | 2.7 | 24 | 1.4 | 0.024 | 1.83(1.08-3.10) |
| AC+CC | 463 | 31.1 | 472 | 28.1 | 0.045 | 1.17(1.00-1.37) |
| A allele | 2473 | 83.1 | 2858 | 85.2 | 0.021 | |
| C allele | 503 | 16.9 | 496 | 14.8 | ||
| rs9344 | ||||||
| AA | 429 | 28.8 | 520 | 31.0 | 0.247 | 1.00 (reference) |
| AG | 740 | 49.7 | 831 | 49.6 | 0.203 | 1.11(0.94-1.32) |
| GG | 319 | 21.4 | 326 | 19.4 | 0.046 | 1.24(1.00-1.52) |
| AG+GG | 1059 | 71.2 | 1157 | 69.0 | 0.098 | 1.17(0.98-1.34) |
| A allele | 1598 | 53.7 | 1871 | 55.8 | 0.096 | |
| G allele | 1378 | 46.3 | 1483 | 44.2 | ||
| rs678653 | ||||||
| CC | 1079 | 72.5 | 1259 | 75.1 | 0.120 | 1.00 (reference) |
| CG | 380 | 25.5 | 397 | 23.7 | 0.283 | 1.10(0.93-1.29) |
| GG | 29 | 1.9 | 21 | 1.3 | 0.199 | 1.47(0.82-2.65) |
| CG+GG | 409 | 27.5 | 418 | 24.9 | 0.192 | 1.11(0.95-1.31) |
| C allele | 2538 | 85.3 | 2915 | 86.9 | 0.061 | |
| G allele | 438 | 14.7 | 439 | 13.1 | ||
* Adjusted for age, sex, BMI, smoking status, drinking status, diabetes and hypertension in logistic regression model. CI, confidence interval; OR, odds ratio.