Table 3. Analysis between combined risk alleles and RCC Susceptibility.
| rs1944129 and rs7177 | Cases (n = 1488) | Controls (n = 1677) | P* | Adjusted OR (95% CI)* | ||
|---|---|---|---|---|---|---|
| N | % | N | % | |||
| Number of risk alleles | ||||||
| 0 | 768 | 51.6 | 893 | 53.2 | 1.00 (reference) | |
| 1 | 265 | 17.8 | 370 | 22.1 | 0.127 | 0.86(0.71-1.04) |
| 2 | 375 | 25.2 | 358 | 21.3 | 0.018 | 1.24(1.04-1.48) |
| 3 | 61 | 4.1 | 44 | 2.6 | 0.009 | 1.72(1.15-2.58) |
| 4 | 19 | 1.3 | 12 | 0.7 | 0.280 | 1.52(0.71-3.24) |
| Recombined groups | ||||||
| 0–1 | 1033 | 69.4 | 1263 | 75.3 | 1.00 (reference) | |
| 2–4 | 455 | 30.6 | 414 | 24.7 | <0.001 | 1.35(1.15-1.58) |
*Two-sided x2 test for either genotype distributions or allele frequencies between the cases and controls. Adjusted for age, smoking status, drinking status and family history of cancer in logistic regression model; 95% CI: 95% confidence interval. The 0–4 represents the numbers of risk alleles within the combined genotypes; the risk alleles used for the calculation were the rs1944129 and rs7177 alleles.