Table 5. Association between the combined genotypes of rs1944129 and rs7177 polymorphisms and clear cell renal cell carcinoma in stratified analysis.
| Variables | Risk allele | P* | Adjusted OR (95% CI)* | |||
|---|---|---|---|---|---|---|
| 0-1 | 2-4 | |||||
| Case(n,%) | Control(n,%) | Case(n,%) | Control(n,%) | |||
| Age | ||||||
| <60 | 616 (59.6) | 741 (58.7) | 277 (60.9) | 234 (56.5) | 0.001 | 1.42 (1.15-1.75) |
| ≥60 | 417 (40.4) | 522 (41.3) | 178 (39.1) | 180 (43.5) | 0.064 | 1.27 (0.98-1.64) |
| Sex | ||||||
| Male | 650 (65.9) | 832 (65.9) | 292 (64.2) | 281 (67.9) | 0.014 | 1.42 (1.07-1.86) |
| Female | 383 (37.1) | 431 (34.1) | 163 (35.8) | 133 (32.1) | 0.008 | 1.31 (1.07-1.61) |
| BMI | ||||||
| <24 | 516 (50.0) | 683 (54.1) | 214 (47.0) | 219 (52.9) | 0.029 | 1.29 (1.03-1.62) |
| ≥24 | 517 (50.0) | 580 (45.9) | 241 (53.0) | 195 (47.1) | 0.003 | 1.42 (1.13-1.79) |
| Smoking status | ||||||
| Never | 635 (61.5) | 845 (66.9) | 287 (63.1) | 270 65.2) | <0.001 | 1.44 (1.18-1.76) |
| Ever | 398 (38.5) | 418 (33.1) | 168 (36.9) | 144 (34.8) | 0.1 | 1.26 (0.96-1.66) |
| Drinking status | ||||||
| Never | 751 (72.7) | 964 (76.3) | 341 (74.9) | 321 (77.5) | 0.001 | 1.36 (1.13-1.63) |
| Ever | 282 (27.3) | 299 (23.7) | 114 (25.1) | 93 (22.5) | 0.105 | 1.33 (0.94-1.87) |
| Family | ||||||
| No | 960 (92.9) | 1156 (91.5) | 420 (92.3) | 379 (91.5) | 0.001 | 1.34 (1.13-1.58) |
| Yes | 73 (7.1) | 107 (8.5) | 35 (7.7) | 35 (8.5) | 0.114 | 1.65 (0.89-3.08) |
| Hypertension | ||||||
| No | 638 (61.8) | 949 (75.1) | 269 (59.1) | 310 (74.9) | 0.008 | 1.30 (1.07-1.58) |
| Yes | 395 (38.2) | 314 (24.9) | 186 (40.9) | 104 (25.1) | 0.008 | 1.47 (1.10-1.97) |
| Diabetes | ||||||
| No | 877 (84.9) | 1185 (93.8) | 418 (91.9) | 387 (93.5) | <0.001 | 1.42 (1.20-1.67) |
| Yes | 156 (15.1) | 78 (6.2) | 37 (8.1) | 27 (6.5) | 0.324 | 0.74 (0.40-1.35) |
* Two-sided χ2 test for number of risk alleles in cases and controls; 95% CI: 95% confidence. Adjusted for age, pack-years of smoking, drinking status, and family history of cancer in logistic regression model.