Table 2. Genotype and allele frequencies of 4 SNPs between case and control group.
| SNPs | Genotypes and alleles | Frequencies N (%) | OR (95%CI)* | p- values | P- values for HWE test in controls | |
|---|---|---|---|---|---|---|
| Controls (n=662) | Cases (n=660) | |||||
| rs2228527 | ||||||
| Co-dominant | ||||||
| AA | 410 (61.9) | 332 (50.3) | 1.00 (ref) | 0.722 | ||
| AG | 220 (33.2) | 266 (40.3) | 1.58 (1.19-2.04) | 0.001 | ||
| GG | 32 (4.8) | 62 (9.4) | 2.01 (1.37-2.76) | <0.001 | ||
| Dominant | ||||||
| AA | 410 (61.9) | 332 (50.3) | 1.00 (ref) | |||
| AG+GG | 252 (38.1) | 328 (49.7) | 1.76 (1.24-2.37) | <0.001 | ||
| Allele, G (%) | 284 (21.4) | 390 (29.5) | ||||
| rs2228529 | ||||||
| Co-dominant | ||||||
| AA | 408 (61.6) | 319 (48.2) | 1.00 (ref) | 0.138 | ||
| AG | 215 (32.5) | 272 (41.1) | 1.52 (1.14-1.99) | 0.0012 | ||
| GG | 39 (5.9) | 71 (10.7) | 1.91 (1.42-2.46) | <0.001 | ||
| Dominant | ||||||
| AA | 408 (61.6) | 319 (48.2) | 1.00 (ref) | |||
| AG+GG | 254 (38.4) | 343 (51.8) | 1.66 (1.24-2.13) | <0.001 | ||
| Allele, G (%) | 293 (22.1) | 414 (31.3) | ||||
| rs4134822 | ||||||
| Co-dominant | ||||||
| GG | 587 (88.7) | 594 (89.7) | 1.00 (ref) | 0.122 | ||
| GA | 75 (11.3) | 68 (10.3) | 1.12 (0.74-1.54) | 0.624 | ||
| AA | 0 (0) | 0 (0) | ||||
| Allele, A (%) | 75 (5.7) | 68 (5.1) | ||||
| rs1799793 | ||||||
| Co-dominant | ||||||
| AA | 379 (57.2) | 339 (51.4) | 1.00 (ref) | 0.127 | ||
| AG | 234 (35.3) | 255 (38.6) | 1.20 (0.79-1.74) | 0.579 | ||
| GG | 49 (7.4) | 66 (10.0) | 1.41 (0.82-2.06) | 0.706 | ||
| Dominant | ||||||
| AA | 379 (57.2) | 339 (51.4) | 1.00 (ref) | |||
| AG+GG | 283 (42.7) | 321 (48.6) | 1.22 (0.80-1.84) | 0.628 | ||
| Allele, G (%) | 332 (25.1) | 387 (29.3) | ||||
* Adjusted for gender, age, BMI, smoking and alcohol drinking.